XML documentation
One of my more long-term pet projects is a version of the wxWindows class documentation that is structured in XML rather than the quite loosely tex format.
Also, this is used in the IRC bot 'wxOracle' (thanks Brian Victor! :)) on #wxwindows on irc (freenode):
11:53 < raboof:#wxwidgets> @describe wxMouseEvent::GetPosition
11:53 < wxOracle:#wxwidgets> wxPoint GetPosition ()
11:53 < wxOracle:#wxwidgets> void GetPosition (wxCoord* x, wxCoord* y)
11:53 < wxOracle:#wxwidgets> void GetPosition (long* x, long* y)
11:53 < wxOracle:#wxwidgets> Sets *x and *y to the position at which the
event occurred. Returns the physical mouse
position in pixels.